Anti-Secretogranin II antibodies are used for the immunodetection of the protein encoded by the SCG2 gene. In humans, the canonical protein has a reported length of 617 amino acid residues and a mass of 70.9 kDa. It is known to be a secreted protein. A member of the Chromogranin/secretogranin protein family, it is reported to be a neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. Post-translational modifications have been described, including O-glycosylation.
The secretogranin II marker can be used to characterize Prostate Gland Endocrine-Paracrine Cells.* Other names for this target antigen include EM66, SN, SgII, secretogranin-2, chromogranin-C, secretoneurin, and CHGC. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of Secretogranin II antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4