Anti-TUBB4B antibodies are used in the immunodetection of the protein tubulin beta 4B class IVb. In humans, the canonical protein has a reported length of 445 amino acid residues and a mass of 49.8 kDa. Its subcellular localization is in the cytoplasm. It is ubiquitously expressed across many tissue types. A member of the Tubulin protein family, TUBB4B is known to be involved with cytoskeleton organization and the cell cycle. Post-translational modifications have been described, including phosphorylation.
The TUBB4B marker can be used to identify Airway Submucosal Gland Ciliated Duct Cells, Bronchus Ciliated Cells, Lung Ciliated Cells, Tracheobronchial Tree Ciliated Columnar Cells, and Submucosal Gland Ciliated Cells.* Synonyms for this target antigen include LCAEOD, TUBB2, TUBB2C, tubulin beta-4B chain, class IVb beta tubulin, and Beta2. TUBB4B gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species. Over 2500 citations in the literature describe the use of TUBB4B antibodies in research. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4