Anti-BPIFA1 antibodies are used in the immunodetection of the protein BPI fold containing family A member 1. In humans, the canonical protein has a reported length of 256 amino acid residues and a mass of 26.7 kDa. It has been described to be a secreted protein. Up to 2 different isoforms have been reported for this protein. It is reported to be highly expressed in the lung, upper airways and nasopharyngeal regions, including trachea and nasal epithelium. A member of the Plunc protein family, BPIFA1 is reported to be a lipid-binding protein, which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC).
The BPIFA1 marker can be used to identify Airway Submucosal Gland Collecting Duct Epithelial Cells.* Synonyms for this target antigen include NASG, PLUNC, SPLUNC1, SPURT, bA49G10.5, ligand-binding protein RYA3, lung-specific protein X, and LUNX. BPIFA1 gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species. A number of BPIFA1 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4