Anti-T-cell immunoreceptor with Ig and ITIM domains antibodies are protein reagents that detect specific antigens. The T-cell immunoreceptor with Ig and ITIM domains antigen is another term for the human protein T cell immunoreceptor with Ig and ITIM domains, encoded by the TIGIT gene. The protein is known to bind with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. Canonically, it has an amino acid length of 244 residues and a mass of 26.3 kilodaltons. Its subcellular localization is in the cell membrane and it is reported to be expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells.