Anti-JAB antibodies are protein reagents that detect specific antigens. The JAB antigen is another term for the human protein suppressor of cytokine signaling 1, encoded by the SOCS1 gene. The protein is known to be an important negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF). Canonically, it has an amino acid length of 211 residues and a mass of 23.6 kilodaltons. Its subcellular localization is in the nucleus and cytoplasmic vesicles and it is reported to be expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes. The JAB protein is a member of the SOCS1 protein family. Other alias names for JAB include AISIMD, CIS1, and CISH1. Western Blot is the most common application for the JAB antibodies listed below. ELISA and Immunohistochemistry are also common applications.