Anti-PRKACA antibodies are used in the immunodetection of the protein protein kinase cAMP-activated catalytic subunit alpha. In humans, the canonical protein has a reported length of 351 amino acid residues and a mass of 40.6 kDa. Its subcellular localization is in the cell membrane, nucleus, cytoplasmic vesicles, mitochondria, and cytoplasm. Up to 2 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the AGC Ser/Thr protein kinase protein family, PRKACA is known to be involved with GPCR signaling pathways and carbohydrate metabolism and homeostasis. Synonyms for this target antigen include PKACA, PPNAD4, cAMP-dependent protein kinase catalytic subunit alpha, PKA C-alpha, and CAFD1. PRKACA gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species. Over 420 citations in the literature describe the use of PRKACA antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.