Anti-CRTAM antibodies are used in the immunodetection of the protein cytotoxic and regulatory T cell molecule. In humans, the canonical protein has a reported length of 393 amino acid residues and a mass of 44.6 kDa. Its subcellular localization is in the cell membrane. Up to 2 different isoforms have been reported for this protein. A member of the Nectin protein family, CRTAM is known to mediate heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets (By similarity). Post-translational modifications have been described, including glycosylation.
The CRTAM marker can be used to identify CD8+ ?ß Memory T Cells.* Synonyms for this target antigen include class-I MHC-restricted T-cell-associated molecule. CRTAM gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 60 citations in the literature describe the use of CRTAM antibodies in research. These antibodies are most commonly used in Flow Cytometry experiments, among other applications.
*HuBMAP Human Reference Atlas v1.4