Anti-IRS1 antibodies are used in the immunodetection of the protein insulin receptor substrate 1. In humans, the canonical protein has a reported length of 1242 amino acid residues and a mass of 131.6 kDa. IRS1 is believed to mediate the control of various cellular processes by insulin. Post-translational modifications have been described, including ubiquitination and phosphorylation. The IRS1 gene has been associated with the disease, Type 2 diabetes mellitus. Synonyms for this target antigen include HIRS-1. IRS1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 1200 citations in the literature describe the use of IRS1 antibodies in research. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.