Anti-USP14 antibodies are used in the immunodetection of the protein ubiquitin specific peptidase 14. In humans, the canonical protein has a reported length of 494 amino acid residues and a mass of 56.1 kDa. Its subcellular localization is in the cell membrane and cytoplasm. Up to 3 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the Peptidase C19 protein family, USP14 is reported to be a proteasome-associated deubiquitinase, which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Synonyms for this target antigen include Ubp6, ubiquitin carboxyl-terminal hydrolase 14, deubiquitinating enzyme 14, tRNA-guanine transglycosylase, 60-kD subunit, and TGT. USP14 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 60 citations in the literature describe the use of USP14 antibodies in research. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.