Anti-CCNH antibodies are used in the immunodetection of the protein cyclin H. In humans, the canonical protein has a reported length of 323 amino acid residues and a mass of 37.6 kDa. Its subcellular localization is in the nucleus. It is notably expressed in many tissues, such as the testis and urinary bladder. A member of the Cyclin protein family, CCNH is reported to regulate CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex.
The CCNH marker can be used to identify T Follicular Helper Cells.* Synonyms for this target antigen include CycH, p34, p37, CAK complex subunit, CDK-activating kinase complex subunit, and CAK. CCNH gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of CCNH antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4