Anti-PTEN antibodies are used in the immunodetection of the protein phosphatase and tensin homolog. In humans, the canonical protein has a reported length of 403 amino acid residues and a mass of 47.2 kDa. Its subcellular localization is in the nucleus and cytoplasm. It is noted to be expressed at a relatively high level in all adult tissues, including heart, brain, placenta, lung, liver, muscle, kidney and pancreas. A member of the PTEN phosphatase protein family, PTEN is known to act as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Post-translational modifications have been described, including ubiquitination and phosphorylation. The PTEN gene has been associated with the disease, Cowden syndrome. Synonyms for this target antigen include BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, and 10q23del. PTEN gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.