Anti-PLEKHG3 antibodies are used in the immunodetection of the protein pleckstrin homology and RhoGEF domain containing G3. In humans, the canonical protein has a reported length of 1219 amino acid residues and a mass of 134.4 kDa. Its subcellular localization is in the cytoplasm. Up to 3 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. PLEKHG3 is reported to play a role in controlling cell polarity and cell motility by selectively binding newly polymerized actin and activating RAC1 and CDC42 to enhance local actin polymerization. Synonyms for this target antigen include KIAA0599, pleckstrin homology domain-containing family G member 3, PH domain-containing family G member 3, pleckstrin homology domain containing, family G (with RhoGef domain) member 3, and ARHGEF43. PLEKHG3 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. ELISA, Western Blot, and Immunohistochemistry are common applications for PLEKHG3 antibodies.