Anti-PSG4 antibodies are used in the immunodetection of the protein pregnancy specific beta-1-glycoprotein 4. In humans, the canonical protein has a reported length of 419 amino acid residues and a mass of 47.1 kDa. It has been described to be a secreted protein. Up to 3 different isoforms have been reported for this protein. It is notably expressed in the placenta and testis. A member of the CEA protein family, PSG4 is known to be involved with signal transduction pathways. Post-translational modifications have been described, including glycosylation.
The PSG4 marker can be used to identify Syncytiotrophoblasts (STB).* Synonyms for this target antigen include PSBG-9, PSG9, PS-beta-G-4, PS-beta-G-9, pregnancy-specific glycoprotein 4, and PSBG-4. PSG4 gene orthologs have been reported in the mouse and chimpanzee species. Immunohistochemistry is the most common application for the PSG4 antibodies listed below. ELISA, Western Blot, Immunocytochemistry, and Immunofluorescence are also common applications.
*HuBMAP Human Reference Atlas v1.4