Anti-triadin antibodies are used for the immunodetection of the protein encoded by the TRDN gene. In humans, the canonical protein has a reported length of 729 amino acid residues and a mass of 81.6 kDa. Its subcellular localization is in the cell membrane. Alternative splicing is reported to yield 3 different isoforms for this protein. It is said to contribute to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Post-translational modifications have been described, including N-glycosylation and phosphorylation.
The triadin marker can be used to characterize Brain Ependymal Non-Neuronal Cells.* Other names for this target antigen include CPVT5, TDN, TRISK, triadin in skeletal muscle, and CARDAR. Gene orthologs have been identified in the mouse, rat, frog, zebrafish, chimpanzee and chicken species. A number of triadin antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4