Anti-H1-8 antibodies are used in the immunodetection of the protein H1.8 linker histone. In humans, the canonical protein has a reported length of 346 amino acid residues and a mass of 35.8 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 2 different isoforms have been reported for this protein. It is reported to have oocyte-specific expression. A member of the Histone H1/H5 protein family, H1-8 is believed to play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Synonyms for this target antigen include H1 histone family member O oocyte specific, histone H1oo, oocyte-specific histone H1, oocyte-specific linker histone H1, and histone H1.8. H1-8 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species.