Anti-MARS1 antibodies are used in the immunodetection of the protein methionyl-tRNA synthetase 1. In humans, the canonical protein has a reported length of 900 amino acid residues and a mass of 101.1 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 2 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the Class-I aminoacyl-tRNA synthetase protein family, MARS1 is known to catalyze the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. The MARS1 gene has been associated with the disease, Interstitial lung and liver disease. Synonyms for this target antigen include CMT2U and ILFS2. MARS1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.