Anti-ABCA13 antibodies are used in the immunodetection of the protein ATP binding cassette subfamily A member 13. In humans, the canonical protein has a reported length of 5058 amino acid residues and a mass of 576.2 kDa. Its subcellular localization is in the cytoplasmic vesicles. Up to 7 different isoforms have been reported for this protein. A member of the ABC transporter protein superfamily, ABCA13 is believed to mediate the cholesterol and gangliosides transport from the plasma membrane to intracellular vesicles in an ATP hydrolysis dependent manner, thus playing a role in their internalization by endocytic retrograde transport and may also participate in the endocytosis of synaptic vesicle in cortical neurons.
The ABCA13 marker can be used to identify Hippocampal Gyrus CA1-3 Neurons and Upper Rhombic Lip Neurons.* Synonyms for this target antigen include ATP binding cassette transporter A13 and ATP-binding cassette, sub-family A (ABC1), member 13. ABCA13 gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species. Some ABCA13 antibodies may have been used in research and have associated citations. ELISA is a widely used application for these antibodies. Western Blot and Immunofluorescence are also common applications.
*HuBMAP Human Reference Atlas v1.4