Anti-ALAS2 antibodies are used in the immunodetection of the protein 5'-aminolevulinate synthase 2. In humans, the canonical protein has a reported length of 587 amino acid residues and a mass of 64.6 kDa. Its subcellular localization is in the mitochondria. Up to 4 different isoforms have been reported for this protein. It is reported to have [isoform 1]: erythroid-specific expression. A member of the Class-II pyridoxal-phosphate-dependent aminotransferase protein family, ALAS2 is known to catalyze the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products.
The ALAS2 marker can be used to identify Late Erythroid Cells and Erythroid Lineage Cells.* Synonyms for this target antigen include ALASE, ANH1, ASB, SIDBA1, XLDPP, XLEPP, XLSA, and ALAS-E. ALAS2 gene orthologs have been reported in the mouse, rat, bovine, frog and chimpanzee species. A number of ALAS2 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. In addition, Immunofluorescence is also a common application.
*HuBMAP Human Reference Atlas v1.4