Anti-CBX5 antibodies are used in the immunodetection of the protein chromobox 5. In humans, the canonical protein has a reported length of 191 amino acid residues and a mass of 22.2 kDa. Its subcellular localization is in the nucleus. It is notably widely expressed in many tissue types. CBX5 is known to be a component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. Post-translational modifications have been described, including ubiquitination and phosphorylation. Synonyms for this target antigen include HP1, HP1A, chromobox protein homolog 5, HP1 alpha homolog, HP1-ALPHA, HP1Hs alpha, antigen p25, and HEL25. CBX5 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 110 citations in the literature describe the use of CBX5 antibodies in research. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.