Anti-gamma-aminobutyric acid type A receptor subunit beta 2 antibodies are used for the immunodetection of the protein encoded by the GABRB2 gene. In humans, the canonical protein has a reported length of 512 amino acid residues and a mass of 59.2 kDa. Its subcellular localization is in the cytoplasmic vesicles and cell membrane. Alternative splicing is reported to yield 4 different isoforms for this protein. A member of the Ligand-gated ion channel (TC 1.A.9) protein family, it is known to be involved with chemical synaptic transmission. Post-translational modifications have been described, including glycosylation. The gene encoding this protein is implicated in Epileptic encephalopathy. Other names for this target antigen include ICEE2, gamma-aminobutyric acid receptor subunit beta-2, GABA(A) receptor subunit beta-2, gamma-aminobutyric acid A receptor beta 2, gamma-aminobutyric acid type A receptor beta2 subunit, and DEE92. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.