Anti-sodium channel epithelial 1 subunit alpha antibodies are used for the immunodetection of the protein encoded by the SCNN1A gene. In humans, the canonical protein has a reported length of 669 amino acid residues and a mass of 75.7 kDa. Its subcellular localization is in the cell membrane, cytoplasmic vesicles, and cytoplasm. Alternative splicing is reported to yield 6 different isoforms for this protein. It is reported to be expressed in the female reproductive tract, from the fimbrial end of the fallopian tube to the endometrium. It is a member of the Amiloride-sensitive sodium channel (TC 1.A.6) protein family. Post-translational modifications have been described, including N-glycosylation, ubiquitination and protein cleavage. The gene encoding this protein is implicated in Pseudohypoaldosteronism. Other names for this target antigen include ENaCa, ENaCalpha, LIDLS3, PHA1B1, SCNEA, SCNN1, amiloride-sensitive sodium channel subunit alpha, and BESC2. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species.