Anti-prion protein antibodies are used for the immunodetection of the protein encoded by the PRNP gene. In humans, the canonical protein has a reported length of 253 amino acid residues and a mass of 27.7 kDa. Its subcellular localization is in the Golgi and cell membrane. A member of the Prion protein family, it is known to be involved with the cell cycle and the regulation of apoptosis. Post-translational modifications have been described, including N-glycosylation. The gene encoding this protein is implicated in Creutzfeldt-Jakob disease. Other names for this target antigen include AltPrP, CD230, CJD, GSS, KURU, PRIP, PrP, and ASCR. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 120 citations in the literature describe the use of prion protein antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.