Anti-EYA2 antibodies are used in the immunodetection of the protein EYA transcriptional coactivator and phosphatase 2. In humans, the canonical protein has a reported length of 538 amino acid residues and a mass of 59.2 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 3 different isoforms have been reported for this protein. It is reported to be highly expressed in muscle with lower levels in the kidney, placenta, pancreas, brain and heart. A member of the EYA protein family, EYA2 is reported to function both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5.
The EYA2 marker can be used to identify Brain Medium Spiny Neurons, Eccentric Medium Spiny Neurons, and Lower Rhombic Lip Neurons.* Synonyms for this target antigen include EAB1 and eyes absent homolog 2. EYA2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of EYA2 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4