Anti-TRAT1 antibodies are used in the immunodetection of the protein T cell receptor associated transmembrane adaptor 1. In humans, the canonical protein has a reported length of 186 amino acid residues and a mass of 21.2 kDa. Its subcellular localization is in the cell membrane. It is reported to be highly expressed in thymus, and to a lesser extent in spleen, lymph node and peripheral blood lymphocytes. TRAT1 is known to be involved with adaptive immune responses and signal transduction pathways. Post-translational modifications have been described, including phosphorylation. The TRAT1 marker can be used to identify CD4 Naïve Cells and Regulatory T Cells.* Synonyms for this target antigen include TCRIM, TRIM, pp29/30, T-cell receptor-associated transmembrane adapter 1, T cell receptor interacting molecule, and HSPC062. TRAT1 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4