Anti-MCUB antibodies are used in the immunodetection of the protein mitochondrial calcium uniporter dominant negative subunit beta. In humans, the canonical protein has a reported length of 336 amino acid residues and a mass of 39.1 kDa. Its subcellular localization is in the mitochondria. It is notably expressed in many tissues, such as the bone marrow, tonsil, and appendix. A member of the MCU (TC 1.A.77) protein family, MCUB is reported to negatively regulate the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion.
The MCUB marker can be used to identify Deep-Layer Intratelencephalic Neurons, Cerebral Cortex MGE Interneurons, and Thalamic Excitatory Neurons.* Synonyms for this target antigen include calcium uniporter regulatory subunit MCUb, mitochondrial, coiled-coil domain containing 109B, coiled-coil domain-containing protein 109B, and CCDC109B. MCUB gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Some MCUB antibodies may have been used in research and have associated citations. ELISA is a widely used application for these antibodies. Western Blot and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4