Anti-TP63 antibodies are used in the immunodetection of the protein tumor protein p63. In humans, the canonical protein has a reported length of 680 amino acid residues and a mass of 76.8 kDa. Its subcellular localization is in the nucleus. Up to 12 different isoforms have been reported for this protein. It is reported to be widely expressed, notably in the heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. A member of the P53 protein family, TP63 is known to act as a sequence specific DNA binding transcriptional activator or repressor.
The TP63 marker can be used to identify Airway Submucosal Gland Duct Basal Cells, Respiratory Suprabasal Cells, Tracheobronchial Tree Basal Epithelial Cells, Epithelium Lobular Bronchiole Basal Cells, and Epithelium Terminal Bronchiole Basal Cells.* Synonyms for this target antigen include B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, and AIS. TP63 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 590 citations in the literature describe the use of TP63 antibodies in research. Immunohistochemistry is a widely used application for these antibodies. Western Blot, Immunocytochemistry, and Immunofluorescence are also common applications.
*HuBMAP Human Reference Atlas v1.4