Anti-BEX1 antibodies are used in the immunodetection of the protein brain expressed X-linked 1. In humans, the canonical protein has a reported length of 125 amino acid residues and a mass of 14.9 kDa. Its subcellular localization is in the nucleus and cytoplasm. It is reported to be expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. A member of the BEX protein family, BEX1 is known to be involved with cell differentiation and nervous system development. Post-translational modifications have been described, including ubiquitination and phosphorylation.
The BEX1 marker can be used to identify Hematopoietic Stem Cells (HSC) and Neuro-Medullary Thymic Epithelial Cells.* Synonyms for this target antigen include brain-expressed X-linked protein 1, ovarian granulosa cell 13.0 kDa protein hGR74, and protein BEX1. BEX1 gene orthologs have been reported in the mouse, rat and chimpanzee species. Some BEX1 antibodies may have been used in research and have associated citations. ELISA, Western Blot, and Immunohistochemistry are common applications for these antibodies.
*HuBMAP Human Reference Atlas v1.4