Anti-serine protease 16 antibodies are used for the immunodetection of the protein encoded by the PRSS16 gene. In humans, the canonical protein has a reported length of 514 amino acid residues and a mass of 55 kDa. Its subcellular localization is in the cytoplasmic vesicles. It is reported to be highly expressed in cortical thymic epithelial cells. A member of the Peptidase S28 protein family, it is a reported protease that may play a role in T-cell development. Post-translational modifications have been described, including glycosylation.
The serine protease 16 marker can be used to characterize Cortical Thymic Epithelial Cells.* Other names for this target antigen include thymus-specific serine protease, protease, serine 16, protease, serine, 16 (thymus), thymus specific serine peptidase, and TSSP. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish and chimpanzee species. Some serine protease 16 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.
*HuBMAP Human Reference Atlas v1.4