Anti-GRIK1 antibodies are used in the immunodetection of the protein glutamate ionotropic receptor kainate type subunit 1. In humans, the canonical protein has a reported length of 918 amino acid residues and a mass of 104 kDa. Its subcellular localization is in the cell membrane. Up to 2 different isoforms have been reported for this protein. It is notably expressed in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus. A member of the Glutamate-gated ion channel (TC 1.A.10.1) protein family, GRIK1 is known to be involved with nervous system development and chemical synaptic transmission.
The GRIK1 marker can be used to identify Midbrain Splatter Neurons and Retinal Bipolar Neuron.* Synonyms for this target antigen include EEA3, GLR5, GLUR5, GluK1, gluR-5, glutamate receptor ionotropic, kainate 1, GluK1(del_e2), and EAA3. GRIK1 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. A number of GRIK1 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunocytochemistry, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4