Anti-ADAMTS12 antibodies are used in the immunodetection of the protein ADAM metallopeptidase with thrombospondin type 1 motif 12. In humans, the canonical protein has a reported length of 1594 amino acid residues and a mass of 177.7 kDa. Its subcellular localization is in the extracellular matrix and is secreted. Up to 3 different isoforms have been reported for this protein. It is reported to be expressed in skeletal muscle and fat. ADAMTS12 is a reported metalloprotease that may play a role in the degradation of COMP. Post-translational modifications have been described, including N-glycosylation and protein cleavage.
The ADAMTS12 marker can be used to identify Thalamic Excitatory Neurons.* Synonyms for this target antigen include a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12, and A disintegrin and metalloproteinase with thrombospondin motifs 12. ADAMTS12 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of ADAMTS12 antibodies have been mentioned in research publications and have associated citations. Immunohistochemistry is a widely used application for these antibodies. ELISA, Western Blot, and Immunofluorescence are also common applications.
*HuBMAP Human Reference Atlas v1.4