Anti-synaptotagmin 6 antibodies are used for the immunodetection of the protein encoded by the SYT6 gene. In humans, the canonical protein has a reported length of 510 amino acid residues and a mass of 57.3 kDa. Its subcellular localization is in the cytoplasmic vesicles and cell membrane. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the Synaptotagmin protein family, it is suspected to be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.
The synaptotagmin 6 marker can be used to characterize Deep-Layer Corticothalamic And 6B Neurons.* Other names for this target antigen include synaptotagmin VI. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species. Some synaptotagmin 6 antibodies may have been used in research and have associated citations. ELISA is a widely used application for these antibodies. Western Blot and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4