Anti-MACROH2A2 antibodies are used in the immunodetection of the protein macroH2A.2 histone. In humans, the canonical protein has a reported length of 372 amino acid residues and a mass of 40.1 kDa. Its subcellular localization is in the nucleus. It is notably widely expressed in many tissue types. MACROH2A2 is known to be involved with brain development and the regulation of transcription. Synonyms for this target antigen include H2A histone family member Y2, core histone macroH2A2.2, histone macroH2A2, mH2A2, and core histone macro-H2A.2. MACROH2A2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.