Anti-KLRF1 antibodies are used in the immunodetection of the protein killer cell lectin like receptor F1. In humans, the canonical protein has a reported length of 231 amino acid residues and a mass of 26.6 kDa. Its subcellular localization is in the membrane. Up to 4 different isoforms have been reported for this protein. It is reported to be highly expressed in peripheral blood leukocytes and spleen, with weaker expression in lymph node and adult liver, and no expression detected in bone marrow, thymus, and fetal liver. KLRF1 is reported to be involved in natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts. Post-translational modifications have been described, including glycosylation.
The KLRF1 marker can be used to identify Natural Killer Cells.* Synonyms for this target antigen include NKp80, killer cell lectin-like receptor subfamily F member 1, C-type lectin domain family 5 member C, activating coreceptor NKp80, and CLEC5C. KLRF1 gene orthologs have been reported in the mouse, rat and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4