Anti-COL8A2 antibodies are used in the immunodetection of the protein collagen type VIII alpha 2 chain. In humans, the canonical protein has a reported length of 703 amino acid residues and a mass of 67.2 kDa. Its subcellular localization is in the extracellular matrix and is secreted. It is notably expressed in the subendothelium of large blood vessels. COL8A2 is reported to be a macromolecular component of the subendothelium. Post-translational modifications have been described, including protein cleavage. The COL8A2 gene has been associated with the disease, Corneal dystrophy. Synonyms for this target antigen include FECD1, PPCD, PPCD2, collagen alpha-2(VIII) chain, collagen VIII, alpha-2 polypeptide, and FECD. COL8A2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some COL8A2 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.