Anti-MACROH2A1 antibodies are used in the immunodetection of the protein macroH2A.1 histone. In humans, the canonical protein has a reported length of 369 amino acid residues and a mass of 39.2 kDa. Its subcellular localization is in the nucleus. Up to 3 different isoforms have been reported for this protein. It is widely expressed across many tissue types. A member of the Histone H2A protein family, MACROH2A1 is known to be involved with DNA repair and the response to oxidative stress. Post-translational modifications have been described, including ubiquitination. Synonyms for this target antigen include H2A/y, H2AF12M, H2AFY, MACROH2A1.1, mH2A1, macroH2A1.2, core histone macro-H2A.1, and H2A.y. MACROH2A1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.