Anti-SUFU antibodies are used in the immunodetection of the protein SUFU negative regulator of hedgehog signaling. In humans, the canonical protein has a reported length of 484 amino acid residues and a mass of 53.9 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 3 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the SUFU protein family, SUFU is known to be involved with the regulation of cell differentiation. Post-translational modifications have been described, including ubiquitination and phosphorylation. Synonyms for this target antigen include JBTS32, PRO1280, SUFUH, SUFUXL, suppressor of fused homolog, negative regulator of hedgehog signaling, and BCNS2. SUFU gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 70 citations in the literature describe the use of SUFU antibodies in research. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.