Anti-PYHIN1 antibodies are used in the immunodetection of the protein pyrin and HIN domain family member 1. In humans, the canonical protein has a reported length of 492 amino acid residues and a mass of 55.1 kDa. Its subcellular localization is in the nucleus. Up to 6 different isoforms have been reported for this protein. It is reported to be expressed in spleen, lymph node and peripheral blood leukocytes, and at lower levels in thymus, bone marrow and fetal liver. A member of the HIN-200 protein family, PYHIN1 is reported to be a major mediator of the tumor suppressor activity of IFN in breast cancer cells. Synonyms for this target antigen include pyrin and HIN domain-containing protein 1 and interferon-inducible protein X. PYHIN1 gene orthologs have been reported in the mouse and chimpanzee species. Some PYHIN1 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.