Anti-TRPV5 antibodies are used in the immunodetection of the protein transient receptor potential cation channel subfamily V member 5. In humans, the canonical protein has a reported length of 729 amino acid residues and a mass of 82.6 kDa. Its subcellular localization is in the cell membrane. Up to 2 different isoforms have been reported for this protein. It is notably expressed at high levels in the kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum. A member of the Transient receptor (TC 1.A.4) protein family, TRPV5 is known to be involved with the transport of ions.
The TRPV5 marker can be used to identify Type 2 Distal Convoluted Tubule Cells and Connecting Tubule Cells.* Synonyms for this target antigen include calcium transporter 2, epithelial calcium channel 1, osm-9-like TRP channel 3, and calcium transport protein 2. TRPV5 gene orthologs have been reported in the mouse, rat and chimpanzee species. A number of TRPV5 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4