Anti-NDRG1 antibodies are used in the immunodetection of the protein N-myc downstream regulated 1. In humans, the canonical protein has a reported length of 394 amino acid residues and a mass of 42.8 kDa. Its subcellular localization is in the cell membrane, nucleus, and cytoplasm. Up to 3 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the NDRG protein family, NDRG1 is known to be a stress-responsive protein involved in hormone responses, cell growth, and differentiation. Post-translational modifications have been described, including phosphorylation.
The NDRG1 marker can be used to identify Thalamic Excitatory Neurons.* Synonyms for this target antigen include CMT4D, DRG-1, DRG1, GC4, HMSNL, NDR1, NMSL, and CAP43. NDRG1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 310 citations in the literature describe the use of NDRG1 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4