Anti-ID3 antibodies are used in the immunodetection of the protein inhibitor of DNA binding 3. In humans, the canonical protein has a reported length of 119 amino acid residues and a mass of 13 kDa. Its subcellular localization is in the nucleus. It is noted to be expressed abundantly in the lung, kidney and adrenal gland, but not in adult brain. ID3 is known to be involved with cell differentiation and nervous system development.
The ID3 marker can be used to identify Cerebral Cortex Astrocytes.* Synonyms for this target antigen include bHLHb25, DNA-binding protein inhibitor ID-3, ID-like protein inhibitor HLH 1R21, class B basic helix-loop-helix protein 25, and HEIR-1. ID3 gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species. A number of ID3 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4