Anti-NDST4 antibodies are used in the immunodetection of the protein N-deacetylase and N-sulfotransferase 4. In humans, the canonical protein has a reported length of 872 amino acid residues and a mass of 100.7 kDa. Its subcellular localization is in the Golgi. Up to 2 different isoforms have been reported for this protein. A member of the Sulfotransferase 1 protein family, NDST4 is known to be an important bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Post-translational modifications have been described, including glycosylation.
The NDST4 marker can be used to identify Midbrain Splatter Neurons and Amygdala Excitatory Neurons.* Synonyms for this target antigen include N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4, N-deacetylase/N-sulfotransferase 4, N-heparan sulfate sulfotransferase 4, and bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4. NDST4 gene orthologs have been reported in the mouse, rat and bovine species.
*HuBMAP Human Reference Atlas v1.4