A Better Choice for Inflammation Research Currently, rhIL-12 is produced in non-human cell systems including insect and CHO. However, it’s becoming apparent that human-specific post-translational modifications, in particular glycosylation, are important to human protein function. Apollo has purified human cell-expressed IL-12 (IL-12hcx) from modified human 293 cells. Research carried out to compare the glycan structures and in vitro biological activities of IL-12hcx to that of CHO-expressed IL-12 in human peripheral mononuclear cells, demonstrated that Apollo’s IL-12hcx has greater biological activity. This was shown through increased activation of STAT molecules, increased production of IFN-ã, increased cell proliferation and enhanced cytolytic activity of PBMC.
Human Cell-Expressed IL-12
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