By preserving post-translational modifications, Electron Capture Dissociation (ECD) allows definitive PTM site and type determinations - making it a powerful tool in biomarker research and drug discovery. Prior to the launch of the Hitachi NanoFrontier LCMS, ECD was only available in FTMS instruments. The time scale of ECD FTMS scans limits the ability to perform LC-based high-throughput analyses. The Hitachi NanoFrontier, with TOF MS, provides high-throughput intelligent control of combined ECD and CID scans for unparalleled interrogation of modified proteins.
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