Custom Laboratory Services

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Contract Manufacturing Services (3)

Calbiotech, Inc

Catalog Number: Contract Manufacturing
Description
: Calbiotech Contract Manufacturing Services:
- Microplate Coating
- Reagent Preparation
- Bottling, Labeling and Packaging
Calbiotech's highly trained technical support staff can assist in the set-up and execution of your manufacturing projects. Calbiotech performs in-process and QC release testing on each production batch to ensure accuracy and precision testing, stability testing and inter/intra lot correlations all pass specifications. All services are offered from our fully validated cGMP and ISO 13485:2003 manufacturing facility in San Diego, California. Our fast set-up times, flexible quantities and ability to provide products according to clients' formulation, packaging and labeling requirements sets us apart as the go-to partner for some of the world's leading laboratories, bio/pharma and diagnostic companies.

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Agilent CrossLab Services

Agilent Technologies

Catalog Number:
Description: Orchestrate productivity across your whole lab with Agilent CrossLab Services

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Agilent Lab Resource Management

Agilent Technologies

Catalog Number:
Description: Optimized lab-wide service with Lab Resource Management

Agilent Lab Resource Management (LRM) is a tailored lab-wide service program designed to improve the efficiency of laboratory operations while delivering guaranteed savings on total service costs. Through streamlined multi-vendor service management, valuable asset and service-level reporting, and harmonized regulatory compliance services, Agilent Lab Resource Management gives you one integrated instrument service model across many techniques and brands.

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Specialty Magnets

Agilent Technologies

Catalog Number:
Description: Custom built superconducting magnets

Agilent provides premium quality magnets, built to the highest engineering standards and practices. The Magnet Technology Center has the capacity to meet a wide range of customer requirements with its extensive expertise, innovative magnet development processes, and access to high performance resources and materials. Agilent's specialty superconducting magnets can be built for individual purposes and customer requirements. Our magnets are optimized for ease of use and installation as well as lower ownership costs. Read the history of the Magnet technology center and its capability to produce high quality specialty magnets.

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Biology CRO Services

Altogen Labs

Catalog Number: CRO-10013
Description: Altogen Labs provides GLP-compliant life science research services, including a variety of pre-clinical studies, pharmacology and toxicology studies, IC-50, microorganism identification services, development of stable cell lines, custom liposome encapsulation, and in vivo siRNA delivery services.

Also offer complete A-to-Z RNAi gene silencing services: gene targeting, siRNA synthesis, chemical modification, functional in vitro validation, siRNA encapsulation, in vivo siRNA protection, and tissue targeted delivery.

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Bioremediation Products and Services

Altogen Labs

Catalog Number: CRO-10018
Description: Products and Services Bioremediation is a process that uses microorganisms, bacteria, fungi, green plants, and their enzymes to restore the environment to its original state after contamination. Bioremediation has been used for centuries after corruption of soil by salt, sewage, and other contaminants, particularly in agriculture. Bioremediation of soil or water following contamination by crude oil is performed by a variety of bacteria that feed on hydrocarbons, breaking down the petroleum molecules into less harmful substances. These naturally occurring bacteria can potentially be isolated and expanded to help remediate oil spills, an approach well accepted by nature with minimal threat to marine ecosystems.

Altogen Labs successfully isolated oil-degrading microbes from polluted soil near Galveston, Texas. These microbes were shown in laboratory tests to be highly effective in bioremediation of petroleum-saturated earth. A method was developed to cultivate oil-degrading bacteria specific to the site of a particular spill, microbes that act on the hydrocarbon molecules present at the polluted site. The bacteria are grown in large volumes in an aqueous solution, from which the water is eventually evaporated to yield a high concentration of bacteria in dry form and low volume.

The product is very stable and the dry bacteria can be activated by simply re-introducing a water-based solution. The growth conditions for these natural bacterial strains were optimized for effective oil degradation in Texas soil. Optimization included considering variables in temperature, soil conditions, and oil composition such that these microbes could be used to remediate contaminated soil on-site when reintroduced in large numbers. This technology offers great potential for cleaning up contaminated soil due to rupture of underground storage tanks, pesticides, percolation of contaminated surface water, oil and fuel dumping, leaching of wastes from landfills, and direct discharge of industrial wastes to the soil.

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Bioremediation: Oil-degrading Bacteria Products and Services

Altogen Labs

Catalog Number: CRO-10019
Description: Bioremediation: Oil-degrading Bacteria Products and Services Most bioremediation products are nutrient-based additives or non-specific microbial cultures which lack efficiency in field tests and applications. Altogen Labs is currently working to develop a superior microbiology systems to improve microbial culture effectiveness. Oil-degrading bacteria, which occur naturally in the environment, are of particular interest to bioremediation companies and scientists because of the positive impact of these bacteria on remediating oil spills in the planet’s oceans and soil. Contamination of the earth’s oceans by oil can be both man-made and naturally occurring. Each year, some 250 million liters of petroleum enter the marine environment from natural seepage. These leaks from the ocean floor contain aromatic compounds that are toxic to most life forms and can cause major ecological insults.

However, despite its toxicity to most organisms, a considerable percentage of petroleum entering marine systems is eliminated by the hydrocarbon-degrading activities of various microbial communities, in particular, by a recently discovered group of microbes known as hydrocarbonoclastic bacteria (HCB). Of this group, the bacterium Alcanivorax borkumensis was the first HCB to have its genome sequenced by scientists and is now the subject of study by researchers around the world.

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Pre-clinical biology CRO Services

Altogen Labs

Catalog Number: CRO-10001
Description: Altogen Labs provides preclinical research and biology CRO services, including xenograft animal models, PK/PD and biodistribution in vivo studies, generation of stable cell lines, RNAi gene silencing, cell banking, siRNA in vitro and in vivo transfection services, IC-50 assays, microorganism identification by 16S gene sequencing. Altogen Labs offer following in vivo services for efficacy studies in the drug discovery phase: mouse xenograft models, teratoma formation and analysis, disease animal models, in vivo siRNA targeting and tissue delivery, pharmacokinetics (PK) and pharmacodynamics (PD) services, immune response and biomarker analysis.

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Service: In Vivo Stable siRNA and microRNA

Altogen Labs

Catalog Number: CRO-10027
Description: In Vivo Stable siRNA and microRNA RNAi-induced gene silencing is used to study gene function in cultured cells, however this approach does not allow a critical evaluation of gene function within the whole organism. Unfortunately, application of RNAi in vivo may present many technical challenges due to siRNA stability, delivery efficiency, and tissue targeting. Performing RNAi experiments in animals can be laborious, time-consuming, expensive, and present numerous technical challenges. Altogen Labs offer complete A-to-Z RNAi services, including in vivo siRNA development, chemical modification of siRNA (increase stability in serum), siRNA encapsulation into liposome, siRNA tissue targeting, qRT-PCR assay to measure siRNA accumulation, biodistribution, functional target mRNA knockdown, reduction of protein expression, off-target effects, immune system response, and many other RNAi in vivo services.

Altogen Labs provides complete in vivo siRNA development services, encapsulation, and tissue targeted delivery. Multiple siRNA administration routes, local and systemic: Intravenous, Intraperitoneal, Intranasal, Intratumoral, Intratracheal, Intradermal, Intramuscular, Intrathecal, Intracerebellar, Intravascular perfusion.

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Service: Liposome Encapsulation of mRNA, Protein, and DNA

Altogen Labs

Catalog Number: CRO-10015
Description: Liposome Encapsulation of mRNA, Protein, and DNA Liposomes can be used to protect cargo molecules (e.g., DNA, RNA, or protein) in vivo and enhance intracellular delivery. Liposomes can be used for the highly efficient delivery of cargo molecules (protein, DNA, RNA) into cells both in vitro and in vivo.

Altogen Labs offers encapsulation of any negatively charged molecuIes (e.g., mRNA, siRNA, shRNA, microRNA, plasmid DNA, and protein) into either one of several standard liposome formulations (PC:Cholesterol and DSPC:Cationic Lipid:PEGylated Lipoid:Cholesterol) or a custom liposome formulation. Sonication and liposome extrusion methods allow the generation of liposomes of a defined size (from 100 to 400 nm). The customer should provide at least 0.5 mg siRNA for liposome encapsulation. Liposome-encapsulated siRNAs are delivered to the customer.

Altogen Labs offers encapsulation services for many different molecules into either one of several standard liposome formulations (PC:Cholesterol and DSPC:Cationic Lipid: PEGylated Lipoid:Cholesterol) or a custom liposome formulation. Microfluidization (microfluidics), extrusion and sonication methods are available to generate liposomes of a defined size. The client is required to provide at least 0.25 mg of material for liposome encapsulation. Custom liposome formulations are available to provide in vivo protection, reduce the innate immune response, and reduce cytotoxicity.

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Service: Liposome Encapsulation of siRNA, microRNA, shRNA

Altogen Labs

Catalog Number: CRO-10016
Description: Liposome Encapsulation of siRNA, microRNA, shRNA Liposomal encapsulation of siRNA, microRNA, shRNA, and plasmid DNA molecules: Liposomes are composite structures made of phospholipids that can be made to encapsulate various types of molecules within the aqueous core of the liposome. Liposomes are used for efficient delivery of cargo molecules (such as siRNA, mRNA, DNA, RNA, protein) into cells in vitro and in vivo. Altogen Labs offer encapsulation of charged molecuIes (siRNA, shRNA, microRNA, mRNA, plasmid DNA, protein) into one of the standard liposomes (PC:Cholesterol and DSPC:Cationic Lipid: PEGylated Lipoid:Cholesterol) or using custom liposome formulation. Sonication and liposome extrusion methods allow to generate liposomes of defined size (from 50 nm to 400 nm particles). Customer should provide at least 0.1 mg of cargo molecule siRNA for liposome encapsulation.

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Service: RNAi manufacturing and CRO services

Altogen Labs

Catalog Number: CRO-10025
Description: RNAi manufacturing and CRO services Altogen Labs provides a complete siRNA design, sythesis, and chemical modification services, as well as service for preparing DNA templates and synthesizing hairpin shRNAs. Purification of the resulting shRNAs and preparation for transfection into cultured cells are offered as well. Also available: custom siRNA libraries, RNAi manufacturing, QC validation, and cell-based assay development services. mRNA Amplification Altogen Labs uses the T7 promoter (tagged polydT) primer for priming first strand cDNA synthesis. Double-stranded cDNA is used as a template for in vitro transcription. In addition to standard ribonucleotides, company scientists also incorporate modified nucleotides (e.g., aminoallyl-UTP) to produce labeled RNA probes and amplifies the original mRNA more than 1 million-fold. RNA is also purified and prepared for all additional applications.

Gene Knockdown by shRNAs
The customer provides the name and accession numbers of the target genes, mails the cells and primary antibodies for Western blotting analysis to Altogen Labs, and the lab team does the rest .

Altogen’s knockdown service includes design, construction, and confirmation of the 3'-5' sequence the shRNA vectors for every target gene. Design and synthesis of the SYBR-labeled qPCR primers for quantitation of target gene expression, shRNA transfection into the cell line supplied by the customer, and targeted gene expression analysis by qPCR at 24, 48, and 72 hr post-transfection and Western blot at 48 and 72 hr after transfection are performed by company scientists.

Altogen Labs guarantees 70% or more inhibition of target gene expression. Transfection controls includes the negative vector control with scrambled sequences (21 bp) and a GFP protein vector control for assessment of transfection efficiency.

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siRNA liposome encapsulation service

Altogen Labs

Catalog Number: CRO-10032
Description: siRNA liposome encapsulation service Liposomes are used for the highly efficient delivery of cargo molecules (DNA, RNA, and protein) into cells both in vitro and in vivo. Altogen Labs offers encapsulation of negatively charged molecuIes (e.g., siRNAs, shRNAs, microRNAs, mRNAs, plasmid DNAs, and proteins) into either one of several standard liposome formulations (PC:Cholesterol and DSPC:Cationic Lipid:PEGylated Lipoid:Cholesterol) or a custom liposome formulation. Sonication, liposome extrusion, and microfluidization (microfluidics) methods allow the generation of liposomes of a defined size (from 50 nm to 400 nm). The customer should provide at least 0.25 mg siRNA for liposome encapsulation. Liposome-encapsulated siRNAs are delivered to the customer. Custom experimental design is available to provide in vivo siRNA protection (in the liposomal core), PEG-modifications to reduce the innate immune response, and low cytotoxicity using biodegradable lipids and polymers.

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PhaseZERO® Fatty Oxidation Assay

Asterand plc

Catalog Number:
Description: Determination of fatty acid oxidation in hepatocytes in response to standard and test compounds. Useful for the lead optimization for diabetes compounds or to investigate potential compound side-effects.

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Custom TaqMan Copy Number Assay, LG

Life Technologies

Catalog Number: 4400296
Description: Custom TaqMan. Copy Number Assay LG

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Custom TaqMan Copy Number Assay, MED

Life Technologies

Catalog Number: 4400295
Description: Custom TaqMan. Copy Number Assay MED

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Custom TaqMan Copy Number Assay, SM

Life Technologies

Catalog Number: 4400294
Description: Custom TaqMan. Copy Number Assay SM

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Integration Solutions

PerkinElmer

Catalog Number: service
Description
: OnPoint^SM Integration Solutions
A partner that understands your application needs

PerkinElmer's OnPoint Integration Solutions comprise an enhanced consultative business approach to custom application services, integration solutions, and new automation technology development for building custom solutions to fit your needs. Whether it's helping a lab automate a specific application, or designing a new automation system specifically for your assay or reagent solution, Integration Solutions has the tools you need.
At PerkinElmer, we understand your application and automation needs are unique, across a wide range of technologies and methods. To meet these varied requirements, our Integration Solutions Services take a team-based approach to addressing each customer's individual circumstances. PerkinElmer provides a dedicated team and deep expertise in both automation and applications, with global coverage, including sites in the United States and Europe.
The OnPoint Integration Solutions Services include:
- Application Development
- Liquid Handling Solutions
- System Integration
- Technology Development
- New Product Development
- OEM Partnerships

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Consulting Service

Raybiotech, Inc.

Catalog Number: CONSULT-SERV
Description: Consulting Service

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Product Development Program

Raybiotech, Inc.

Catalog Number: CUST-PROG

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ADDITIONAL COLONY EXPANSIONS per clone

Rockland Immunochemicals, Inc.

Catalog Number: MAB-004
Description: Step 7 of the Rockland Immunochemical's complete service includes up to five (5) positive parental clones. Additional subcloning and expansion can be performed at the customer's request on a per clone basis.

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BIOPROCESSING

Rockland Immunochemicals, Inc.

Catalog Number: MAB-090
Description: Antibodies produced from hybridoma cell lines can be characterized for epitope mapping, native protein reaction, cross-reaction and titration using immunoprecipitation, immunoblotting and various ELISA methods. Please inquire for additional details.

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Concentration by Ultrafiltration

Rockland Immunochemicals, Inc.

Catalog Number:

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Concentration by Ultrafiltration

Rockland Immunochemicals, Inc.

Catalog Number: CUST80M

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CROSS ADSORPTION

Rockland Immunochemicals, Inc.

Catalog Number: CUST90
Description: CROSS ADSORPTION - up to 100 ml of serum or 100 ml of ascites or 500 ml of processed and concentrated tissue culture supernate is adsorbed to removed unwanted reactivity. Specify cross.

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CUSTOM BUFFY COAT PREPARATION

Rockland Immunochemicals, Inc.

Catalog Number: CUST57
Description: CUSTOM BUFFY COAT PREPARATION - Buffy coat preparation from up to 200 ml of blood by centrifugation and sedimentation to enrich for leukocytes (PBMC). Does not include cost of blood.

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Custom HPLC Analysis

Rockland Immunochemicals, Inc.

Catalog Number: CUST70
Description: High Performance Liquid Chromatography (HPLC) is an analytical technique used to separate, identify and quantify compounds in a wide array of samples from a broad spectrum of industries. Let Rockland’s expertise aid you in separating and purifying your protein or antibody. Protein purification schemes usually involve multiple separations and isolations. Furthermore, two purification methods may be employed together to increase the degree of purification. We offer Size Exclusion Chromatography, Ion Exchange and other resin formats. Charge applies per sample applied to column.

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Custom Lyophilization Services

Rockland Immunochemicals, Inc.

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Draft And Final Report

Rockland Immunochemicals, Inc.

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Draft And Final Report

Rockland Immunochemicals, Inc.

Catalog Number: CUST65M

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