Genetic Stability Testing
from
ACGT, Inc.
Description
ACGT, Inc. offers genetic stability testing to characterize Master Cell Banks (MCB), Working Cell Banks (WCB), and End of Production Cells (EPC) from bacterial, yeast, and cell cultures. The analysis process starts with isolation of a sufficient number of clones to adequately sample the population of cells in the culture. The characterization of single clone isolates ensures that the presence of cells with missing or mutated genetic elements in the cell bank is insignificant.
Restriction mapping, Southern blot analysis and sequencing are performed on DNA prepared from the clones. We also provide sequence verification by direct analysis of RT-PCR fragments targeting the appropriate mRNA of the MCB as well as the WCB and EPC.