Rabbit Anti-IRS2, phospho (Ser731) Polyclonal Antibody, Unconjugated
from
GeneTex
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Product
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Rabbit Anti-IRS2, phospho (Ser731) Polyclonal Antibody, Unconjugated
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Company
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GeneTex
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Price
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Pricing Info
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More Information
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View Company Product Page
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Target
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IRS2, phospho (Ser731)
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Catalog Number
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GTX23690
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Quantity
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100 ug
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Reactivity
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This antibody isspecific for human IRS 2 phosphorylated at the position ofSerine 731. The antibodies were evaluated for specificitywith a dot blot assay using synthetically prepared IRSpeptides. It only recognizes the phosphorylated serine 731,not other phosphorylated sites or non-phosphorylated IRS 1 or IRS 2.
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Conjugate/Tag/Label
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Unconjugated
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Applications
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ELISA, IP, WB
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Host
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Rabbit
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Type
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Polyclonal Antibody
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Isotype
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IgG
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Form
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0.5 mg/ml. Immunogen affinity purified.
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Original Item Name
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Rabbit polyclonal to IRS2 (phospho S731)
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Description
Rabbit polyclonal to IRS2 (phospho S731)
The insulin receptor mediates insulin action through the phosphorylation of substrate proteins. The major substrates of the insulin receptor kinase are the insulin receptor substrate (IRS) family of proteins, IRS 1, IRS 2, IRS 3, and IRS 4. IRS 2, a cytoplasmic signaling molecule that mediates effects of insulin, Insulin-like growth factor 1 and other cytokines by acting as a molecular adaptor between diverse receptor kinases and downstream effectors. IRS proteins contain more than 70 potential Ser / Thr phosphorylation sites for kinases like PKA (cAMP-dependent protein kinase), PKC, and MAPK. The phosphorylation of Ser / Thr residues of IRS proteins has a dual function, serving either for a positive or negative modulation of insulin signal transduction.
Immunogen: Synthetic peptide (YKASpSPAESS)corresponding to amino acids 727-736 of human IRS 2 atthe phosphorylated site of Serine 731. This syntheticpeptide also correlates to amino acids 129-138 of mouseIRS 2 at the phosphorylation sites of Serine 133 and toamino acids 229-238 of rat IRS 2 at the serinephosphorylation site 233.
Specificity: This antibody isspecific for human IRS 2 phosphorylated at the position ofSerine 731. The antibodies were evaluated for specificitywith a dot blot assay using synthetically prepared IRSpeptides. It only recognizes the phosphorylated serine 731,not other phosphorylated sites or non-phosphorylated IRS 1 or IRS 2.