Imject Alum
from
Thermo Scientific Pierce Protein Research Products
Description
Adjuvants are nonspecific stimulators of the immune response. When mixed with an antigen, they help to deposit or sequester the injected material. In addition, they cause a dramatic increase in the resultant antibody response. An adjuvant is not the same thing as a carrier protein. A hapten will become immunogenic when conjugated covalently to a carrier protein. The hapten will not become immunogenic if it is merely added to an adjuvant. Consequently, an adjuvant ehances the immune response to immunogens, but it cannot render haptens immunogenic.
Features
Imject Freunds Complete Adjuvant (FCA) Features/Benefits
- Enhances immune response to immunogen
- Used for initial injections
- Water-in-oil emulsion and killed Mycobacterium
Imject Freunds Complete Adjuvant (FCA) Disadvantages
- Difficult to mix with immunogen
- Can cause tissue necrosis at injection site
Imject Freunds Incomplete Adjuvant (FIA) Features/Benefits
- Used for subsequent boosts after initial injection
- No Mycobacterium present; mix with immunogen
Imject Freunds Incomplete Adjuvant (FIA) Disadvantages
- Difficult to mix with immunogen