Bryostatin 1
from
EMD Millipore
Description
Bryo 1
White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A macrocyclic lactone with antitumor properties. Potently activates protein kinase C and exhibits a high binding affinity (Ki = 1.35 nM). Effectively translocates and down-regulates PKC isozymes α, δ, and ε. Induces a biphasic activation of PKD through a PKC-dependent pathway in intact cells. Also shown to activate Ras in Jurkat T cells and in rat2 cells. Purity: ≥98% by TLC. Soluble in DMSO or EtOH. RTECS EH9455000, CAS 83314-01-6, M.W. 905.1.
References
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