Guanosine 3′,5′-cyclic Monophosphorothioate, β-Phenyl-1,N2-etheno-8-bromo-, Sp-Isomer, Sodium Salt
from
EMD Millipore
Description
Sp-8-Br-PET-cGMPS, Na
Lyophilized solid. HYGROSCOPIC. A potent, selective, cell-permeable activator of PKG type Iα (Ka = 2.5 μM) and Iβ (Ka = 2.6 μM). Also acts as an inhibitor of retinal type of cGMP-gated ion channels (IC50 = 105 μM). Does not affect the activity of PKA II (Ka > 1000 μM). Resistant against mammalian cyclic nucleotide-dependent phosphodiesterases and shows no metabolic side effects. More lipophilic and cell-permeable than Sp-8-pGMPS. Purity: ≥98% by HPLC. Soluble in H2O. CAS 172806-21-2, M.W. 562.3. Note: 5 μmol = 2.81 mg.
References
Wei, J.Y., et al. 1996. Biochemistry 35, 16815.Butt, E., et al. 1995. Br. J. Pharmacol. 116, 3110.