Parallel Rod Floor Apparatus, Four Enclosure System
from
Stoelting Co.
Description
Features:
- Ideal for use with transgenic and knockout mice
- Simultaneous measurement of ataxia and locomotor activity
- Unlike the Rota-rod (and similar tests) the Parallel Rod Floor Test allows for corrections in activity levels
- Controlled by ANY-maze Software
The Parallel Rod Floor Apparatus, designed for assessing the effects of drugs, brain damage and disease, on motor coordination and fatigue, is ideal for use with knockout and transgenic mice. This test is a high througput, high yield screening and phenotyping tool intended as a replacement of traditional rotarods and other similar test. Adapted from the apparatus first described and developed by Drs Kamens and Crabbe the Parallel Rod Floor Test is a new model of ataxia in mice.
However, the parallel rod floor test yields two dependent variables not necessarily provided by other test: number of errors (foot slips) and horizontal distance traveled (cm). Using a ratio (errors per cm traveled 100) to index ataxia in this apparatus corrected for individual differences in activity provides a robust and unique measure of genetic contributions to locomotor incoordination. This is in contrast to several other measures of ataxia, such as the Rota-rod, where the parameters of the task (e.g., rate of acceleration of rotation) have been shown to have large effects on the pattern of strain sensitivity.
The Parallel Rod Floor Apparatus is an ANY-maze software driven product (www.anymaze.com); however, a manual system is also available on our website. The software can be used to track as many as 16 Parallel Rod Floor Test simultaneously. The software also includes more than 100 standard measures and performs full statistical analysis of results immediately upon completion of your experiment. For more information, including details about the ANYmaze software, or a list of papers which use this product, please visit our website.